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closeDo yeast get depressed?
Posted by hashimoto on 14 May 2012 at 04:44 GMT
I have read the manuscript. I think this paper is very interesting. The data support a serotonin transporter independent component of antidepressant sertraline. A further study using another SSRIs, including paroxetine and fluvoxamine, may be interesting. In addition, a further study on BDNF-TrkB signaling pathway as well as sigma-1 receptor chaperone will be of great interest since these pathways paly a key role in the pathophysiology of depression.
Academic Editor
Kenji hashimoto
RE: Do yeast get depressed?
eperlste replied to hashimoto on 14 May 2012 at 22:47 GMT
Thanks for your feedback, Kenji.
We are currently studying the membrane-based pharmacology of other SSRIs as well as other psychiatric-disease drugs, like antipsychotics. Preliminary analysis suggests that there are indeed specific drug-membrane interactions, and that different pharmacological classes behave differently in yeast at the genetic level at least.
We are also looking at the BDNF-TrkB pathway as a readout of antidepressant accumulation in cellular membranes of neuronal cell lines.