High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Dhara A. Patel; Anand C. Patel; William C. Nolan; Yong Zhang; Michael J. Holtzman

doi:10.1371/journal.pone.0036594

Loading metrics

Open Access

Peer-reviewed

Research Article

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Dhara A. Patel,

Affiliation Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
⨯
Anand C. Patel,

Affiliations Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri, United States of America
⨯
William C. Nolan,

Affiliation Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
⨯
Yong Zhang,

Affiliation Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America
⨯
Michael J. Holtzman

* E-mail: holtzmanm@wustl.edu

Affiliations Drug Discovery Program, Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Cell Biology, Washington University School of Medicine, Saint Louis, Missouri, United States of America
⨯

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Dhara A. Patel,
Anand C. Patel,
William C. Nolan,
Yong Zhang,
Michael J. Holtzman

Published: May 4, 2012
https://doi.org/10.1371/journal.pone.0036594

Reader Comments

Post a new comment on this article

Media Coverage of This Article

Posted by PLOS_ONE_Group on 11 May 2012 at 21:58 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Washington University in St. Louis
Title: “New technique could identify drugs that help fight broad range of viruses | Newsroom | Washington University in St. Louis”
http://news.wustl.edu/new...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Interferons
Is the Subject Area "Interferons" applicable to this article?

Thanks for your feedback.
Drug screening
Is the Subject Area "Drug screening" applicable to this article?

Thanks for your feedback.
Library screening
Is the Subject Area "Library screening" applicable to this article?

Thanks for your feedback.
Antiviral therapy
Is the Subject Area "Antiviral therapy" applicable to this article?

Thanks for your feedback.
Small molecules
Is the Subject Area "Small molecules" applicable to this article?

Thanks for your feedback.
Luciferase assay
Is the Subject Area "Luciferase assay" applicable to this article?

Thanks for your feedback.
Drug interactions
Is the Subject Area "Drug interactions" applicable to this article?

Thanks for your feedback.
Antivirals
Is the Subject Area "Antivirals" applicable to this article?

Thanks for your feedback.

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Media Coverage of This Article

Posted by PLOS_ONE_Group on 11 May 2012 at 21:58 GMT