Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

Alexander Samoshkin; Alexei Arnaoutov; Lars E. T. Jansen; Ilia Ouspenski; Louis Dye; Tatiana Karpova; James McNally; Mary Dasso; Don W. Cleveland; Alexander Strunnikov

doi:10.1371/journal.pone.0006831

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Research Article

Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

Alexander Samoshkin ,

Contributed equally to this work with: Alexander Samoshkin, Alexei Arnaoutov, Lars E. T. Jansen

Affiliation Unit on Chromosome Structure and Function, National Institute of Child Health and Human Development (NICHD), Laboratory of Gene Regulation and Development (LGRD), Bethesda, Maryland, United States of America
⨯
Alexei Arnaoutov ,

Contributed equally to this work with: Alexander Samoshkin, Alexei Arnaoutov, Lars E. T. Jansen

Affiliation Section on Cell Cycle Regulation, National Institute of Child Health and Human Development (NICHD), Laboratory of Gene Regulation and Development (LGRD), Bethesda, Maryland, United States of America
⨯
Lars E. T. Jansen ,

Contributed equally to this work with: Alexander Samoshkin, Alexei Arnaoutov, Lars E. T. Jansen

Current address: Instituto Gulbenkian de Ciência, Oeiras, Portugal

Affiliation Ludwig Institute For Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Ilia Ouspenski,

Affiliation Unit on Chromosome Structure and Function, National Institute of Child Health and Human Development (NICHD), Laboratory of Gene Regulation and Development (LGRD), Bethesda, Maryland, United States of America
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Louis Dye,

Affiliation National Institute of Child Health and Human Development (NICHD), Laboratory of Functional and Molecular Imaging, Bethesda, Maryland, United States of America
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Tatiana Karpova,

Affiliation Fluorescence Imaging Facility, National Cancer Institute (NCI), Bethesda, Maryland, United States of America
⨯
James McNally,

Affiliation Fluorescence Imaging Facility, National Cancer Institute (NCI), Bethesda, Maryland, United States of America
⨯
Mary Dasso,

Affiliation Section on Cell Cycle Regulation, National Institute of Child Health and Human Development (NICHD), Laboratory of Gene Regulation and Development (LGRD), Bethesda, Maryland, United States of America
⨯
Don W. Cleveland,

Affiliation Ludwig Institute For Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
⨯
Alexander Strunnikov

* E-mail: strunnik@mail.nih.gov

Affiliation Unit on Chromosome Structure and Function, National Institute of Child Health and Human Development (NICHD), Laboratory of Gene Regulation and Development (LGRD), Bethesda, Maryland, United States of America
⨯

Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

Alexander Samoshkin,
Alexei Arnaoutov,
Lars E. T. Jansen,
Ilia Ouspenski,
Louis Dye,
Tatiana Karpova,
James McNally,
Mary Dasso,
Don W. Cleveland,
Alexander Strunnikov

Published: August 28, 2009
https://doi.org/10.1371/journal.pone.0006831

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New insight

Posted by Fyodor_Urnov on 17 Sep 2009 at 17:47 GMT

The Aurora kinases not only target the condensins, but are themselves major targets for drug discovery -- which adds to the impact of this work.

No competing interests declared.

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Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

Human Condensin Function Is Essential for Centromeric Chromatin Assembly and Proper Sister Kinetochore Orientation

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New insight

Posted by Fyodor_Urnov on 17 Sep 2009 at 17:47 GMT