Advertisement
Research Article

Comparison of T Cell Receptor-Induced Proximal Signaling and Downstream Functions in Immortalized and Primary T Cells

  • Rebekah R. Bartelt,

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Noemi Cruz-Orcutt,

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Michaela Collins,

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Jon C. D. Houtman mail

    jon-houtman@uiowa.edu

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

    X
  • Published: May 04, 2009
  • DOI: 10.1371/journal.pone.0005430

Reader Comments (1)

Post a new comment on this article

Required reading for T cell biologists

Posted by ACLellouch on 05 May 2009 at 09:28 GMT

Given the widespread use of the Jurkat cell line, it really is high time that someone has
undertaken a systematic study comparing TCR mediated signalling events in Jurkats vs "real"
T lymphocytes. A great paper that should be required reading for anyone working in TCR and/or costimulatory signalling.

No competing interests declared.