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Research Article

The Origin of Phenotypic Heterogeneity in a Clonal Cell Population In Vitro

  • Daniel Stockholm equal contributor,

    equal contributor Contributed equally to this work with: Daniel Stockholm, Rachid Benchaouir

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Rachid Benchaouir equal contributor,

    equal contributor Contributed equally to this work with: Daniel Stockholm, Rachid Benchaouir

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Julien Picot,

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Philippe Rameau,

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Thi My Anh Neildez,

    Affiliations: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France, Ecole Pratique des Hautes Etudes, Paris, France

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  • Gabriel Landini,

    Affiliation: Oral Pathology Unit, School of Dentistry, The University of Birmingham, Birmingham, England

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  • Corinne Laplace-Builhé,

    Affiliation: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France

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  • Andras Paldi mail

    To whom correspondence should be addressed. E-mail: paldi@genethon.fr

    Affiliations: GENETHON–Centre National de la Recherche Scientifique (CNRS), UMR 8115, Evry, France, Ecole Pratique des Hautes Etudes, Paris, France

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  • Published: April 25, 2007
  • DOI: 10.1371/journal.pone.0000394

Reader Comments (1)

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interesting question, but ...

Posted by suihuang on 10 Jul 2007 at 12:47 GMT

The authors address an important, rather neglected problem: non-genetic hereogeneity of cells in matazoan. The biological implications in terms of a complex system built of autonomous elements (cells) are hardly examined. This paper presents an interesting start, a pretty robust experimental system and a simple, intelligible model. Hopefully it will stimulate more work, notably the development of analysis methods to confirm and more rigorously quantitate the results presented here. Then more sophisticated theoretical models that the one proposed here can be designed and tested...