Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans

Daniela Contu; Laura Morelli; Federico Santoni; Jamie W. Foster; Paolo Francalacci; Francesco Cucca

doi:10.1371/journal.pone.0001430

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Open Access

Peer-reviewed

Research Article

Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans

Daniela Contu ,

Contributed equally to this work with: Daniela Contu, Laura Morelli

Affiliation Laboratorio di Immunogenetica, Ospedale Microcitemico, Cagliari, Italy
⨯
Laura Morelli ,

Contributed equally to this work with: Daniela Contu, Laura Morelli

Affiliation Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy
⨯
Federico Santoni,

Affiliation Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
⨯
Jamie W. Foster,

Current address: Albert Park, Melbourne, Australia

Affiliation Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy
⨯
Paolo Francalacci,

Affiliation Dipartimento di Zoologia e Genetica Evoluzionistica, Università di Sassari, Sassari, Italy
⨯
Francesco Cucca

*To whom correspondence should be addressed. E-mail: fcucca@uniss.it

Affiliation Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy
⨯

Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans

Daniela Contu,
Laura Morelli,
Federico Santoni,
Jamie W. Foster,
Paolo Francalacci,
Francesco Cucca

Published: January 9, 2008
https://doi.org/10.1371/journal.pone.0001430

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Excellent Insight

Posted by vineviz on 11 Jan 2008 at 17:05 GMT

Well-designed and written study! I question one or two genotyping assignments (which impacted the TMRCA estimate for R-M18) and some of model parameters for BATWING, but overall the conclusions seem sound and helpful.

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Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans

Y-Chromosome Based Evidence for Pre-Neolithic Origin of the Genetically Homogeneous but Diverse Sardinian Population: Inference for Association Scans

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Thank You!

Excellent Insight

Posted by vineviz on 11 Jan 2008 at 17:05 GMT