Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase

Ken Dawson-Scully; Gary A. B. Armstrong; Clement Kent; R. Meldrum Robertson; Marla B. Sokolowski

doi:10.1371/journal.pone.0000773

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Peer-reviewed

Research Article

Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase

Ken Dawson-Scully,

Affiliation University of Toronto, Department of Biology, Mississauga, Ontario, Canada
⨯
Gary A. B. Armstrong,

Affiliation Queen's University, Department of Biology, Kingston, Ontario, Canada
⨯
Clement Kent,

Affiliation University of Toronto, Department of Biology, Mississauga, Ontario, Canada
⨯
R. Meldrum Robertson,

Affiliation Queen's University, Department of Biology, Kingston, Ontario, Canada
⨯
Marla B. Sokolowski

*To whom correspondence should be addressed. E-mail: msokolow@utm.utoronto.ca

Affiliation University of Toronto, Department of Biology, Mississauga, Ontario, Canada
⨯

Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase

Ken Dawson-Scully,
Gary A. B. Armstrong,
Clement Kent,
R. Meldrum Robertson,
Marla B. Sokolowski

Published: August 22, 2007
https://doi.org/10.1371/journal.pone.0000773

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well done!

Posted by BjoernBrembs on 03 Oct 2007 at 08:18 GMT

This paper is a wonderful example of how valuable and powerful invertebrate model systems are for a wide variety of biological questions ranging from the single molecule all the way up to ecology and evolution.
In our ever warmer world, the evolution of thermotolerance is a key factor in understanding and predicting species distributions. This study uses two different model systems each with its own technical advantages to study the role of the forager gene product (a PKG) in thermotolerance. The role of the for PKG is evolutionarily conserved so the results presented here help understand the general neurobiology and genetics of thermotolerance. The explanatory power and generalizability of the results are typical for this kind of integrative neuroscience.

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Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase

Natural Variation in the Thermotolerance of Neural Function and Behavior due to a cGMP-Dependent Protein Kinase

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well done!

Posted by BjoernBrembs on 03 Oct 2007 at 08:18 GMT