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Research Article

Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

  • Taras K. Oleksyk mail,

    *E-mail: oleksyk@ncifcrf.gov

    Affiliations: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Kai Zhao,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Francisco M. De La Vega,

    Affiliation: Applied Biosystems, Foster City, California, United States of America

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  • Dennis A. Gilbert,

    Affiliation: Applied Biosystems, Foster City, California, United States of America

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  • Stephen J. O'Brien,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Michael W. Smith

    Affiliations: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Published: March 05, 2008
  • DOI: 10.1371/journal.pone.0001712

Reader Comments (16)

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What,where, when and why of selection in the genomes

Posted by sezgine on 10 Mar 2008 at 23:14 GMT

Authors present a unique way of detecting selection acting on the human genomes. The main strenght of the approach is its potential application on other organisms where genomic sequence and genotype data is produced at an increasing speed.