MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

Yu Lei; Chris B. Moore; Rachael M. Liesman; Brian P. O'Connor; Daniel T. Bergstralh; Zhijian J. Chen; Raymond J. Pickles; Jenny P.-Y. Ting

doi:10.1371/journal.pone.0005466

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Open Access

Peer-reviewed

Research Article

MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

Yu Lei ,

Contributed equally to this work with: Yu Lei, Chris B. Moore

Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Oral Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Chris B. Moore ,

Contributed equally to this work with: Yu Lei, Chris B. Moore

Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Rachael M. Liesman,

Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Brian P. O'Connor,

Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Daniel T. Bergstralh,

Affiliation Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Zhijian J. Chen,

Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
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Raymond J. Pickles,

Affiliation Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Jenny P.-Y. Ting

* E-mail: Jenny_Ting@med.unc.edu

Affiliations Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯

MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

Yu Lei,
Chris B. Moore,
Rachael M. Liesman,
Brian P. O'Connor,
Daniel T. Bergstralh,
Zhijian J. Chen,
Raymond J. Pickles,
Jenny P.-Y. Ting

Published: March 7, 2009
https://doi.org/10.1371/journal.pone.0005466

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Interesting and insightful

Posted by ramy on 05 May 2009 at 06:05 GMT

The study is interesting and the paper is well presented. The figures are also very well done and presented in a very good order. Figure 8 is exceptional as it provides a summary for the paper and a model for MAVS activity.

Competing interests declared: I have participated in a study directed by Dr. Ting and published in 2007 (http://www.jimmunol.org/cgi/content/full/179/9/6291).

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MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

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Interesting and insightful

Posted by ramy on 05 May 2009 at 06:05 GMT