A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells

Sanjeev Mahanta; Shawn P. Fessler; Jaehong Park; Cynthia Bamdad

doi:10.1371/journal.pone.0002054

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Peer-reviewed

Research Article

A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells

Sanjeev Mahanta,

Affiliation Minerva Biotechnologies, Waltham, Massachusetts, United States of America
⨯
Shawn P. Fessler,

Affiliation Minerva Biotechnologies, Waltham, Massachusetts, United States of America
⨯
Jaehong Park,

Affiliation Minerva Biotechnologies, Waltham, Massachusetts, United States of America
⨯
Cynthia Bamdad

* E-mail: cbamdad@minervabio.com

Affiliation Minerva Biotechnologies, Waltham, Massachusetts, United States of America
⨯

A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells

Sanjeev Mahanta,
Shawn P. Fessler,
Jaehong Park,
Cynthia Bamdad

Published: April 30, 2008
https://doi.org/10.1371/journal.pone.0002054

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MUC1* NM23 POSITIVE FEEDBACK LOOP DRIVES CANCER PROLIFERATION

Posted by Monopole on 04 Oct 2008 at 21:53 GMT

MUC1* is shown to be the dominant if not sole MUC1 surface ligand present on human solid tumors. Dimerization of MUC1* by its natural ligand NM23 produced by the same cells forms a 'malignant' positive feedback loop causing cell division and resistance to apoptosis. Insightful groundbreaking work.

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A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells

A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells

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MUC1* NM23 POSITIVE FEEDBACK LOOP DRIVES CANCER PROLIFERATION

Posted by Monopole on 04 Oct 2008 at 21:53 GMT