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Research Article

Stressing the Ubiquitin-Proteasome System without 20S Proteolytic Inhibition Selectively Kills Cervical Cancer Cells

  • Ravi K. Anchoori,

    Affiliations: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Saeed R. Khan,

    Affiliations: Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America, FDA-CDER Division of Product Quality Research, Silver Spring, Maryland, United States of America

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  • Thanasak Sueblinvong,

    Affiliation: Masonic Cancer Center and Department of Obstetrics, Gynecology and Women's Heath, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Alicia Felthauser,

    Affiliation: Masonic Cancer Center and Department of Obstetrics, Gynecology and Women's Heath, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Yoshie Iizuka,

    Affiliation: Masonic Cancer Center and Department of Obstetrics, Gynecology and Women's Heath, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Riccardo Gavioli,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy

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  • Federica Destro,

    Affiliation: Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy

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  • Rachel Isaksson Vogel,

    Affiliation: Masonic Cancer Center and Department of Obstetrics, Gynecology and Women's Heath, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Shiwen Peng,

    Affiliation: Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Richard B. S. Roden,

    Affiliations: Department of Pathology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Gynecology and Obstetrics, Johns Hopkins University, Baltimore, Maryland, United States of America

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  • Martina Bazzaro mail

    mbazzaro@umn.edu

    Affiliation: Masonic Cancer Center and Department of Obstetrics, Gynecology and Women's Heath, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America

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  • Published: August 31, 2011
  • DOI: 10.1371/journal.pone.0023888

Reader Comments (1)

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Degron, etc

Posted by wishfulthinking on 14 Oct 2011 at 16:39 GMT

1. RE: pp 3&9:
Degron is a pre-occupied term definied as a specific sequence of amino acids in a protein that directs the starting place of degradation
2. No error bars or statistics found in majority of figures
3. Mechanism(s)/target(s) for these inhibitors are not shown. Toxicity only?

No competing interests declared.