Advertisement
Research Article

MUC1* Mediates the Growth of Human Pluripotent Stem Cells

  • Sherry T. Hikita,

    Affiliations: Center for Stem Cell Biology and Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Kenneth S. Kosik,

    Affiliations: Center for Stem Cell Biology and Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America, Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Dennis O. Clegg,

    Affiliations: Center for Stem Cell Biology and Engineering, University of California Santa Barbara, Santa Barbara, California, United States of America, Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, California, United States of America, Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America

    X
  • Cynthia Bamdad mail

    cbamdad@minervabio.com

    Affiliation: Minerva Biotechnologies, Waltham, Massachusetts, United States of America

    X
  • Published: October 03, 2008
  • DOI: 10.1371/journal.pone.0003312

Reader Comments (1)

Post a new comment on this article

MUC1* NM23 POSITIVE FEEDBACK LOOP DRIVES PLURIPOTENT STEM CELL DIVISION

Posted by Monopole on 07 Oct 2008 at 16:22 GMT

MUC1* appears to be the true marker of stem cell pluripotency. Dimerization of surface MUC1* with NM23 or specific divalent antibody causes division of pluripotent stem cells without differentiation. A major breakthrough toward making possible the establishment of stable sources of undifferentiated pluripotent stem cells. These authors point to previous work demonstrating MUC1* and its natural ligand NM23 form a positive feedback loop causing cancer cell division and resistance to apoptosis. It appears that the same mechanism responsible for pluripotent stem cell division in embryonic development and turned off in cellular differentiation may through a series of mischances in later life be reactivated in cancers. Brilliant work.