BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis

Lynne A. Murray; Tillie L. Hackett; Stephanie M. Warner; Furquan Shaheen; Rochelle L. Argentieri; Paul Dudas; Francis X. Farrell; Darryl A. Knight

doi:10.1371/journal.pone.0004039

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Open Access

Peer-reviewed

Research Article

BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis

Lynne A. Murray ,

* E-mail: lmurray@promedior.com

Current address: Promedior, Inc, Malvern, Pennsylvania, United States of America

Affiliation Immunobiology Department, Tissue Remodeling and Metabolism Department, Centocor, Radnor, Pennsylvania, United States of America
⨯
Tillie L. Hackett,

Affiliations James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, Canada, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
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Stephanie M. Warner,

Affiliations James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, Canada, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
⨯
Furquan Shaheen,

Affiliations James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, Canada, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
⨯
Rochelle L. Argentieri,

Affiliation Immunobiology Department, Tissue Remodeling and Metabolism Department, Centocor, Radnor, Pennsylvania, United States of America
⨯
Paul Dudas,

Affiliation Immunobiology Department, Tissue Remodeling and Metabolism Department, Centocor, Radnor, Pennsylvania, United States of America
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Francis X. Farrell,

Affiliation Immunobiology Department, Tissue Remodeling and Metabolism Department, Centocor, Radnor, Pennsylvania, United States of America
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Darryl A. Knight

Affiliations James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, Canada, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
⨯

BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis

Lynne A. Murray,
Tillie L. Hackett,
Stephanie M. Warner,
Furquan Shaheen,
Rochelle L. Argentieri,
Paul Dudas,
Francis X. Farrell,
Darryl A. Knight

Published: December 29, 2008
https://doi.org/10.1371/journal.pone.0004039

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A great different Voice

Posted by njzjd08 on 07 Jan 2009 at 19:00 GMT

A great different voice to challenge the "main-stream" role of BMP-7. Interestingly, a similar report in NDT 2008 also indicated that BMP-7 only can attenuate the EMT induced by TGF-beta1 in a few specific cell types

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Fibrosis
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BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis

BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis

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A great different Voice

Posted by njzjd08 on 07 Jan 2009 at 19:00 GMT