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Research Article

Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis

  • Michael P. Walsh,

    Affiliation: Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America

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  • Ashish Chintakuntlawar,

    Affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Christopher M. Robinson,

    Affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ijad Madisch,

    Affiliation: Insitut für Virologie, Medizinische Hochschule, Hannover, Germany

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  • Balázs Harrach,

    Affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary

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  • Nolan R. Hudson,

    Affiliation: Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, California, United States of America

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  • David Schnurr,

    Affiliation: Viral and Rickettsial Disease Laboratory, California Department of Public Health, Richmond, California, United States of America

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  • Albert Heim,

    Affiliation: Insitut für Virologie, Medizinische Hochschule, Hannover, Germany

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  • James Chodosh,

    Affiliation: Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Donald Seto,

    Affiliation: Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America

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  • Morris S. Jones mail

    drmorrisj@yahoo.com

    Affiliation: Clinical Investigation Facility, David Grant USAF Medical Center, Travis AFB, California, United States of America

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  • Published: June 03, 2009
  • DOI: 10.1371/journal.pone.0005635

Reader Comments (1)

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Redefining Adenoviridae

Posted by mejones107 on 09 Jan 2010 at 05:52 GMT

This paper was amazing in several ways. First, it was the most interesting nove virus paper in 2009, because it had biological experiments as part of the study. Second, the recombination analysis was easy to follow and easy to read. Third, naming adenoviruses is something that needs to change. With the advent of whole genome sequencing, it is about time someone came out and decided that serology is cumbersome and outdated as a means of naming adenoviruses.

No competing interests declared.