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Posted by zhaohj2001200310 on 05 Feb 2007 at 05:06 GMT

The role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD) is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene.
http://plosone.org/article/info:doi/10.1371/journal.pone.0000181#article1.front1.article-meta1.abstract1.sec1.p1

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