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closeModifications Requested by the Academic Editor
Posted by PLOS_ONE_Group on 17 Jan 2008 at 10:00 GMT
Please change to (>>)
Abstract
microarrays techniques
>> microarray techniques
Page 3
However, there is a great ignorance about how the "acquired capabilities" of tumor cells would take place;
>> However, little is known about the mechanisms of how "acquired capabilities" of tumor cells arise;
Page 5
To analyze molecular differences
>> To analyze the molecular differences
Although in a minor intensity,
>> Although to a minor degree,
Page 6
No expression difference was found between pre- and post-senescent MSC,
>> No difference in expression was found between pre- and post-senescent MSC,
Microarray analysis showed no mRNA significant differences between pre- and postsenescence MSC
>> Microarray analysis showed no significant differences in mRNA levels between pre- and postsenescence MSC
Page 9
Human MSC in early passage are safe although stressful conditions
>> Human MSC in early passage are safe, although stressful conditions
can turn them in immortal and occasionally they became tumorogenic [6].
>> can turn them into immortal cells and occasionally they can become tumorigenic [6].
better protocols for culture adult stem cells,
>> better protocols for culture of adult stem cells,
as it has been demanded recently [19].
>> as it has been demonstrated recently [19].
PLEASE DISCUSS AND CITE ON PAGE 10, PARAGRAPH 3, THE FOLLOWING PAPER:
Takeuchi et al., Chromosomal instability in human mesenchymal stem cells immortalized with human papilloma virus E6, E7, and hTERT genes. In Vitro Cell.Dev.Biol.-Animal (2007) 43:129-138.
Page 11
Recently it has been published the dependency on oxidative
>> Recent studies have demonstrated the dependency on oxidative
Page 13
or radio-chemically induced maintaining their
>> or radio-chemically induced, maintained their
In sum, all these evidences strongly suggest that cells
>> In summary, these data strongly suggest that cells
events to become a tumor cells.
>> events to become tumor cells.
culture [6] remains to be studied in deep.
>> culture [6] remains to be determined.
Page 17
and met-TMC (15 JU/m2).
>> and met-TMC (15 J/m2).