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closeis that surprising?
Posted by Vincent_Danos on 19 Feb 2011 at 17:28 GMT
de novo proteins are unlike those of any known natural proteins
http://plosone.org/article/info:doi/10.1371/journal.pone.0015364#article1.body1.sec2.sec1.p4
as one is sampling from a large set of possible molecules, i am wondering what would be the chances that any one of them gets close to a known natural one?
RE: is that surprising?
Vincent_Danos replied to Vincent_Danos on 20 Feb 2011 at 09:44 GMT
The above remark is supposed to be a note on the following sentence in the paper "NCBI-BLAST searches indicate the sequences of the de novo proteins are unlike those of any known natural proteins".
More generally it would be nice to know something about the probability distribution of the synthetic proteins on their sequence space, and elements for comparing with natural ones - do all of the sequences fold properly? what is the fraction of natural proteins that follow the same pattern? etc