NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

Hanoch Kaphzan; Kenneth J. O'Riordan; Kile P. Mangan; Jonathan M. Levenson; Kobi Rosenblum

doi:10.1371/journal.pone.0000138

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Peer-reviewed

Research Article

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

Hanoch Kaphzan,

Affiliation Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel
⨯
Kenneth J. O'Riordan,

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Kile P. Mangan,

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Jonathan M. Levenson,

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Kobi Rosenblum

*To whom correspondence should be addressed. E-mail: kobir@psy.haifa.ac.il

Affiliation Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel
⨯

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

Hanoch Kaphzan,
Kenneth J. O'Riordan,
Kile P. Mangan,
Jonathan M. Levenson,
Kobi Rosenblum

Published: December 27, 2006
https://doi.org/10.1371/journal.pone.0000138

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Isn't Jnk and p38 really a conincidence detector?

Posted by emindeniz on 11 Jan 2007 at 21:55 GMT

I don't buy Figure 3 because just like there is more activation in ERK2 with DA+NMDA, the same thing is also true for p38 and Jnk kinases. I think you need much more data.

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NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

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Isn't Jnk and p38 really a conincidence detector?

Posted by emindeniz on 11 Jan 2007 at 21:55 GMT