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Research Article

Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis

  • Farrel J. Buchinsky mail,

    fjbuch@gmail.com

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

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  • Joseph Donfack,

    Affiliation: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America

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  • Craig S. Derkay,

    Affiliation: Eastern Virginia Medical School, Norfolk, Virginia, United States of America

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  • Sukgi S. Choi,

    Affiliation: Children's National Medical Center, Washington, DC, United States of America

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  • Stephen F. Conley,

    Affiliation: Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States of America

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  • Charles M. Myer III,

    Affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • John E. McClay,

    Affiliation: Children's Medical Center of Dallas, Dallas, Texas, United States of America

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  • Paolo Campisi,

    Affiliation: The Hospital for Sick Children, Toronto, Ontario, Canada

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  • Brian J. Wiatrak,

    Affiliation: Children's Hospital of Alabama, Birmingham, Alabama, United States of America

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  • Steven E. Sobol,

    Affiliation: Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • John M. Schweinfurth,

    Affiliation: University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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  • Domingos H. Tsuji,

    Affiliation: Hospital das Clinicas of Sao Paulo University Medical School, Sao Paulo, Brazil

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  • Fen Z. Hu,

    Affiliations: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Departments of Human Genetics, and Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Howard E. Rockette,

    Affiliation: Biostatistics Department, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Garth D. Ehrlich,

    Affiliations: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Departments of Human Genetics, and Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • J. Christopher Post

    Affiliations: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America, Departments of Human Genetics, and Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Published: May 28, 2008
  • DOI: 10.1371/journal.pone.0002263

Reader Comments (2)

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Seedat RY did not observe age-type association

Posted by Farrel on 01 May 2010 at 08:05 GMT

the average age of diagnosis amongst those with HPV 6 was 3.4 years and the average age of diagnosis for those with HPV 11 was 2.4 years (t test p-value = 0.014)
http://plosone.org/article/info:doi/10.1371/journal.pone.0002263#article1.body1.sec2.p8

Seedat et al, analyzed 18 patients and found that the average age of diagnosis amongst those with HPV 6 was 5.4 years and for those with HPV 11 it was 5.3 years. Possible reasons: 1)smaller sample size 2)generally later diagnosis 3)truly different pattern for inexplicable reasons.

see: HPV types causing juvenile recurrent laryngeal papillomatosis in South Africa.
Seedat RY, Thukane M, Jansen AC, Rossouw I, Goedhals D, Burt FJ.
Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):255-9.
PMID: 20018386

No competing interests declared.