In Vitro HIV-1 Selective Integration into the Target Sequence and Decoy-Effect of the Modified Sequence

Tatsuaki Tsuruyama; Tonau Nakai; Takuya Hiratsuka; Guang Jin; Takuro Nakamura; Kenichi Yoshikawa

doi:10.1371/journal.pone.0013841

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Peer-reviewed

Research Article

In Vitro HIV-1 Selective Integration into the Target Sequence and Decoy-Effect of the Modified Sequence

Tatsuaki Tsuruyama ,

* E-mail: tsuruyam@fp.med.kyoto-u.ac.jp

Affiliation Department of Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto Prefecture, Japan
⨯
Tonau Nakai,

Affiliation Department of Physics, Graduate School of Science, Kyoto University, Kyoto, Kyoto Prefecture, Japan
⨯
Takuya Hiratsuka,

Affiliation Laboratory of Pathology, Noe-saiseikai Hospital, Osaka, Osaka Prefecture, Japan
⨯
Guang Jin,

Affiliation Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
⨯
Takuro Nakamura,

Affiliation Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
⨯
Kenichi Yoshikawa

Affiliation Department of Physics, Graduate School of Science, Kyoto University, Kyoto, Kyoto Prefecture, Japan
⨯

In Vitro HIV-1 Selective Integration into the Target Sequence and Decoy-Effect of the Modified Sequence

Tatsuaki Tsuruyama,
Tonau Nakai,
Takuya Hiratsuka,
Guang Jin,
Takuro Nakamura,
Kenichi Yoshikawa

Published: November 4, 2010
https://doi.org/10.1371/journal.pone.0013841

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Publisher's Note: Error in Figure 3 legend

Posted by PLOS_ONE_Group on 13 Jan 2011 at 19:18 GMT

Presence of CA and TG motifs and integration ratio.
http://plosone.org/article/info:doi/10.1371/journal.pone.0013841#pone-0013841-g003

There was an error in the legend of Figure 3. The correct legend is:

Figure 3. Presence of CA and GT motifs and integration ratio.
(A) Number and (B) percentage of PIAP copies from integration into target sequences or sequences lacking 5′-CA-3′ or 5′-GT-3′ dinucleotide motifs (*p<0.001; target vs. CA-; **p<0.001 vs. GT- ; ***p<0.001 vs. CA-GT-; ****p<0.001; target vs. CA-, GT-, CA-GT-). Error bars represent standard deviation (S.E.). The sequences shown display the 6x1y segment of the target DNA. The sequence CA-1GT- in Figure 1 indicates an example of CA-1GT- sequences.

No competing interests declared.

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In Vitro HIV-1 Selective Integration into the Target Sequence and Decoy-Effect of the Modified Sequence

In Vitro HIV-1 Selective Integration into the Target Sequence and Decoy-Effect of the Modified Sequence

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Publisher's Note: Error in Figure 3 legend

Posted by PLOS_ONE_Group on 13 Jan 2011 at 19:18 GMT