A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

Asher Peretz; Nurit Degani-Katzav; Maya Talmon; Eyal Danieli; Anna Gopin; Eti Malka; Rachel Nachman; Amiram Raz; Doron Shabat; Bernard Attali

doi:10.1371/journal.pone.0001332

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Open Access

Peer-reviewed

Research Article

A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

Asher Peretz,

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Nurit Degani-Katzav,

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Maya Talmon,

Affiliation Department of Biochemistry, Georges Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel
⨯
Eyal Danieli,

Affiliation School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel
⨯
Anna Gopin,

Affiliation School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel
⨯
Eti Malka,

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Rachel Nachman,

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯
Amiram Raz,

Affiliation Department of Biochemistry, Georges Wise Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel
⨯
Doron Shabat,

Affiliation School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel
⨯
Bernard Attali

*To whom correspondence should be addressed. E-mail: battali@post.tau.ac.il

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
⨯

A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

Asher Peretz,
Nurit Degani-Katzav,
Maya Talmon,
Eyal Danieli,
Anna Gopin,
Eti Malka,
Rachel Nachman,
Amiram Raz,
Doron Shabat,
Bernard Attali

Published: December 26, 2007
https://doi.org/10.1371/journal.pone.0001332

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Incorrect formula for tolfenamic acid

Posted by Gemma on 20 Jun 2008 at 07:30 GMT

Tolfenamic acid is 2-[(3-chloro-2-methylphenyl)amino]benzoic acid.

The chemical drawing is then incorrect for tolfenamic acid in Figure 3.

Thank you

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A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

A Tale of Switched Functions: From Cyclooxygenase Inhibition to M-Channel Modulation in New Diphenylamine Derivatives

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Incorrect formula for tolfenamic acid

Posted by Gemma on 20 Jun 2008 at 07:30 GMT