Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

Steven E. Schutzer; Thomas E. Angel; Tao Liu; Athena A. Schepmoes; Therese R. Clauss; Joshua N. Adkins; David G. Camp II; Bart K. Holland; Jonas Bergquist; Patricia K. Coyle; Richard D. Smith; Brian A. Fallon; Benjamin H. Natelson

doi:10.1371/journal.pone.0017287

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Open Access

Peer-reviewed

Research Article

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

Steven E. Schutzer ,

Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

* E-mail: schutzer@umdnj.edu

Affiliation Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Thomas E. Angel ,

Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Tao Liu ,

Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
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Athena A. Schepmoes,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
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Therese R. Clauss,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
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Joshua N. Adkins,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
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David G. Camp II,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
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Bart K. Holland,

Affiliation Division of Biostatistics and Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America
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Jonas Bergquist,

Affiliation Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden
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Patricia K. Coyle,

Affiliation Department of Neurology, State University of New York-Stony Brook, Stony Brook, New York, United States of America
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Richard D. Smith,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
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Brian A. Fallon,

Affiliation Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America
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Benjamin H. Natelson

Affiliations Department of Neurology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, Department of Pain Medicine and Palliative Care and Beth Israel Medical Center, Albert Einstein School of Medicine, Bronx, New York, United States of America
⨯

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

Steven E. Schutzer,
Thomas E. Angel,
Tao Liu,
Athena A. Schepmoes,
Therese R. Clauss,
Joshua N. Adkins,
David G. Camp II,
Bart K. Holland,
Jonas Bergquist,
Patricia K. Coyle

Published: February 23, 2011
https://doi.org/10.1371/journal.pone.0017287

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Only 19,000 in normal sample

Posted by kwitwer1 on 11 Apr 2011 at 19:04 GMT

approximately 30,000 peptides for each pooled sample
http://plosone.org/article/info:doi/10.1371/journal.pone.0017287#article1.body1.sec3.sec1.p1

30,000 peptides were identified in the two disease samples. Only ~19,000 peptides were identified in the pooled normal sample (see Table S1).

No competing interests declared.

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Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

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Only 19,000 in normal sample

Posted by kwitwer1 on 11 Apr 2011 at 19:04 GMT