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Research Article

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

  • Steven E. Schutzer equal contributor mail,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    schutzer@umdnj.edu

    Affiliation: Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America

    X
  • Thomas E. Angel equal contributor,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Tao Liu equal contributor,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Athena A. Schepmoes,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Therese R. Clauss,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Joshua N. Adkins,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • David G. Camp II,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Bart K. Holland,

    Affiliation: Division of Biostatistics and Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America

    X
  • Jonas Bergquist,

    Affiliation: Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden

    X
  • Patricia K. Coyle,

    Affiliation: Department of Neurology, State University of New York-Stony Brook, Stony Brook, New York, United States of America

    X
  • Richard D. Smith,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Brian A. Fallon,

    Affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America

    X
  • Benjamin H. Natelson

    Affiliations: Department of Neurology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, Department of Pain Medicine and Palliative Care and Beth Israel Medical Center, Albert Einstein School of Medicine, Bronx, New York, United States of America

    X
  • Published: February 23, 2011
  • DOI: 10.1371/journal.pone.0017287

Reader Comments (4)

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Only 19,000 in normal sample

Posted by kwitwer1 on 11 Apr 2011 at 19:04 GMT

approximately 30,000 peptides for each pooled sample
http://plosone.org/article/info:doi/10.1371/journal.pone.0017287#article1.body1.sec3.sec1.p1

30,000 peptides were identified in the two disease samples. Only ~19,000 peptides were identified in the pooled normal sample (see Table S1).

No competing interests declared.