Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

Xu Shi-wen; Shangxi Liu; Mark Eastwood; Sonali Sonnylal; Christopher P. Denton; David J. Abraham; Andrew Leask

doi:10.1371/journal.pone.0007438

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Peer-reviewed

Research Article

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

Xu Shi-wen,

Affiliation Centre for Rheumatology, Department of Medicine, University College London (Royal Free Campus), London, United Kingdom
⨯
Shangxi Liu,

Affiliation The Canadian Institute of Health Research Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯
Mark Eastwood,

Affiliation School of Biosciences, University of Westminster, London, United Kingdom
⨯
Sonali Sonnylal,

Affiliation University of Texas, M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Christopher P. Denton,

Affiliation Centre for Rheumatology, Department of Medicine, University College London (Royal Free Campus), London, United Kingdom
⨯
David J. Abraham ,

Contributed equally to this work with: David J. Abraham, Andrew Leask

Affiliation Centre for Rheumatology, Department of Medicine, University College London (Royal Free Campus), London, United Kingdom
⨯
Andrew Leask

Contributed equally to this work with: David J. Abraham, Andrew Leask

* E-mail: Andrew.leask@schulich.uwo.ca

Affiliation The Canadian Institute of Health Research Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
⨯

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

Xu Shi-wen,
Shangxi Liu,
Mark Eastwood,
Sonali Sonnylal,
Christopher P. Denton,
David J. Abraham,
Andrew Leask

Published: October 13, 2009
https://doi.org/10.1371/journal.pone.0007438

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Ultraviolet light impact on regulation of Rac in skin

Posted by rsonthei on 30 Jan 2011 at 15:35 GMT

Human clinical evidence suggests that high dose long wave ultraviolet A-1 light (UVA-1 or UVA1) can soften fibrotic skin in humans having localized forms of scleroderma. Based on the data presented in this report, one might question whether UVA-1 might be capable of downregulating Rac gene expression in human sclerodermatous skin.

No competing interests declared.

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Fibroblasts
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Collagens
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Extracellular matrix
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Fibrosis
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Scleroderma
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Transfection
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Hyperexpression techniques
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Protein expression
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Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

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Ultraviolet light impact on regulation of Rac in skin

Posted by rsonthei on 30 Jan 2011 at 15:35 GMT