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Gluconate correction

Posted by CDezzutti on 06 Oct 2011 at 17:48 GMT

To address the disadvantages, the concentration of gluconate in CVL collected in Normosol-R was determined in 20 participants. The recovered cervicovaginal fluid was 235 µl (139.2–304.8 µl; median [range]), a 42-fold dilution of genital tract secretions in a 10 ml CVL.
http://plosone.org/article/info:doi/10.1371/journal.pone.0023136#article1.body1.sec3.sec2.p1

Ongoing quality control of the gluconate assay has uncovered problems with assay performance and data processing. Significant and unpredictable, matrix-interference discovered in an independent re-validation have led us to conclude that gluconate is not a reliable analyte for measuring cervicovaginal fluid dilution. As a result, gluconate adjusted cervicovaginal fluid volumes reported in the manuscript are incorrect and are not correctible. Other findings and conclusions of the study remain unaffected.

No competing interests declared.
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