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Research Article

Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection

  • Monica E. Embers mail,

    members@tulane.edu (MEE); Philipp@tulane.edu (MTP)

    Affiliation: Divisions of Bacteriology & Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Stephen W. Barthold,

    Affiliation: Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Juan T. Borda,

    Affiliation: Comparative Pathology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Lisa Bowers,

    Affiliation: Divisions of Bacteriology & Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Lara Doyle,

    Affiliation: Veterinary Medicine, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Emir Hodzic,

    Affiliation: Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California Davis, Davis, California, United States of America

    X
  • Mary B. Jacobs,

    Affiliation: Divisions of Bacteriology & Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Nicole R. Hasenkampf,

    Affiliation: Divisions of Bacteriology & Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Dale S. Martin,

    Affiliation: Divisions of Bacteriology & Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Sukanya Narasimhan,

    Affiliation: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Kathrine M. Phillippi-Falkenstein,

    Affiliation: Veterinary Medicine, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Jeanette E. Purcell,

    Affiliation: Veterinary Medicine, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    Current address: Biologic Resources Laboratory, University of Illinois, Chicago, Illinois, United States of America

    X
  • Marion S. Ratterree,

    Affiliation: Veterinary Medicine, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Mario T. Philipp mail

    members@tulane.edu (MEE); Philipp@tulane.edu (MTP)

    Affiliation: Divisions of Bacteriology & Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

    X
  • Published: January 11, 2012
  • DOI: 10.1371/journal.pone.0029914

Reader Comments (8)

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antibiotic administered was ceftriaxone

Posted by membersla on 29 Feb 2012 at 23:39 GMT

Ceftiofur sodium, Pfizer Animal Health, Kalamazoo, MI
http://plosone.org/article/info:doi/10.1371/journal.pone.0029914#article1.body1.sec4.sec3.sec1.p2

Rocephin, ceftriaxone sodium, Hoffman-LaRoche Inc.

No competing interests declared.

RE: antibiotic administered was ceftriaxone

rstricker replied to membersla on 02 Mar 2012 at 10:39 GMT

Dear Dr. Embers,

If that is the case, then the article has a serious mistake that has caused significant controversy and needs to be corrected. The published study says that ceftiofur was given to the monkeys. Ceftiofur and ceftriaxone are not the same antibiotic. If you are now saying that ceftriaxone and not ceftiofur was used, you need to ask the journal to publish a correction to the study in order to avoid more misunderstanding and wasted debate.

No competing interests declared.

RE: RE: antibiotic administered was ceftriaxone

inmacdonald replied to rstricker on 02 Mar 2012 at 14:17 GMT

A re-read of the online article On March 2,2012 --
Ceftiotur has been expunged from the text of the article
(which I originally downloaded)
and has been replaced by Ceftriaxone [Rocephin (R)]
I was pleased with the original text, and I am equally pleased
with the present manuscript.
I note with interest the 1998 Rhesus experimental Neuroborreliosis by Dr Gail Habicht (no antbiotics) and the
observations of pathogenesis of peripheral nerve injujry
in untreated brimates with Neuroboreliosis.
With appreciation,

Alan B. MacDonald MD











































A



No competing interests declared.

RE: antibiotic administered was ceftriaxone

Baker replied to membersla on 03 Mar 2012 at 21:23 GMT

With so many authors on this paper, how do you explain this? It can not be a typographical error. Ceftiofur and ceftriaxone are manufactured and supplied by different companies. Was ceftriofur used in any of this work? If so, which aniumals received it?

No competing interests declared.

RE: antibiotic administered was ceftriaxone

Baker replied to membersla on 03 Mar 2012 at 21:24 GMT

How do you explain why this occurred?

No competing interests declared.