GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

Jieru Egeria Lin; Adam Eugene Snook; Peng Li; Brian Arthur Stoecker; Gilbert Won Kim; Michael Sullivan Magee; Alex Vladimir Mejia Garcia; Michael Anthony Valentino; Terry Hyslop; Stephanie Schulz; Scott Arthur Waldman

doi:10.1371/journal.pone.0031686

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Peer-reviewed

Research Article

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

Jieru Egeria Lin ,

Contributed equally to this work with: Jieru Egeria Lin, Adam Eugene Snook, Peng Li

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Adam Eugene Snook ,

Contributed equally to this work with: Jieru Egeria Lin, Adam Eugene Snook, Peng Li

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Peng Li ,

Contributed equally to this work with: Jieru Egeria Lin, Adam Eugene Snook, Peng Li

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Brian Arthur Stoecker,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Gilbert Won Kim,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Michael Sullivan Magee,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Alex Vladimir Mejia Garcia,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Michael Anthony Valentino,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Terry Hyslop,

Affiliation Divison of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Stephanie Schulz,

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Scott Arthur Waldman

* E-mail: Scott.Waldman@Jefferson.edu

Affiliation Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

Jieru Egeria Lin,
Adam Eugene Snook,
Peng Li,
Brian Arthur Stoecker,
Gilbert Won Kim,
Michael Sullivan Magee,
Alex Vladimir Mejia Garcia,
Michael Anthony Valentino,
Terry Hyslop,
Stephanie Schulz

Published: February 22, 2012
https://doi.org/10.1371/journal.pone.0031686

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 24 Feb 2012 at 22:12 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Daily Rx
Title: “Intestinal Barrier Walls Out Cancer | www.dailyrx.com”
http://www.dailyrx.com/ne...

Publication: Eureka Alert
Title: “Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests”
http://www.eurekalert.org...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

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GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 24 Feb 2012 at 22:12 GMT