Advertisement
Research Article

Low-Load High Volume Resistance Exercise Stimulates Muscle Protein Synthesis More Than High-Load Low Volume Resistance Exercise in Young Men

  • Nicholas A. Burd,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Daniel W. D. West,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Aaron W. Staples,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Philip J. Atherton,

    Affiliation: School of Graduate Entry Medicine and Health, City Hospital, University of Nottingham, Derby, United Kingdom

    X
  • Jeff M. Baker,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Daniel R. Moore,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Andrew M. Holwerda,

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Gianni Parise,

    Affiliations: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada, Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada

    X
  • Michael J. Rennie,

    Affiliation: School of Graduate Entry Medicine and Health, City Hospital, University of Nottingham, Derby, United Kingdom

    X
  • Steven K. Baker,

    Affiliation: Department of Neurology, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

    X
  • Stuart M. Phillips mail

    phillis@mcmaster.ca

    Affiliation: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada

    X
  • Published: August 09, 2010
  • DOI: 10.1371/journal.pone.0012033

Reader Comments (9)

Post a new comment on this article

Effects of vascular occlusion?

Posted by overfiftylifter on 27 Sep 2011 at 00:14 GMT

It is possible that one reason for the favorable results using higher rep training is the greater buildup of local metabolites associated with hypertrophy due to the created local ischemic environment? Is it possible that a Kaatsu type effect(lower load higher rep) is produced that some studies show produces similar changes to higher load lifting?

No competing interests declared.