Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse

Elin Lehrmann; Carlo Colantuoni; Amy Deep-Soboslay; Kevin G. Becker; Ross Lowe; Marilyn A. Huestis; Thomas M. Hyde; Joel E. Kleinman; William J. Freed

doi:10.1371/journal.pone.0000114

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Peer-reviewed

Research Article

Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse

Elin Lehrmann ,

*To whom correspondence should be addressed. E-mail: elehrman@intra.nida.nih.gov

Affiliations Cellular Neurobiology Research Branch, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America, Chemistry and Drug Metabolism Section, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
⨯
Carlo Colantuoni,

Affiliation Clinical Brain Disorders Branch, GCAP, National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
⨯
Amy Deep-Soboslay,

Affiliation Clinical Brain Disorders Branch, GCAP, National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
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Kevin G. Becker,

Affiliation Research Resources Branch, National Institute on Aging (NIA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
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Ross Lowe,

Affiliation Chemistry and Drug Metabolism Section, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
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Marilyn A. Huestis,

Affiliation Chemistry and Drug Metabolism Section, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
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Thomas M. Hyde,

Affiliation Clinical Brain Disorders Branch, GCAP, National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
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Joel E. Kleinman,

Affiliation Clinical Brain Disorders Branch, GCAP, National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
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William J. Freed

Affiliation Cellular Neurobiology Research Branch, National Institute on Drug Abuse (NIDA) Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, United States of America
⨯

Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse

Elin Lehrmann,
Carlo Colantuoni,
Amy Deep-Soboslay,
Kevin G. Becker,
Ross Lowe,
Marilyn A. Huestis,
Thomas M. Hyde,
Joel E. Kleinman,
William J. Freed

Published: December 27, 2006
https://doi.org/10.1371/journal.pone.0000114

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function of apoLs

Posted by epays on 08 Jan 2007 at 12:59 GMT

I would like to comment on the distribution and function of apoLs.

Contrary to the information given in this paper,
(1) The apoL genes are not limited to primates, but are also found in other mammals;
(2) There is no evidence that apoLs are involved in trafficking of cholesterol.

As reviewed in Vanhollebeke, B., and Pays, E. (2006) The function of apolipoproteins L. Cell. Mol. Life Sci. 63, 1937-1944, these proteins are likely to play a role in programmed cell death.
In particular, apoL1 was shown to be implicated in trypanolysis by human serum (see: Pays, E., Vanhollebeke, B., Vanhamme, L., Paturiaux-Hanocq, F., Nolan, D.P., and Pérez-Morga, D. (2006) The trypanolytic factor of human serum. Nature Reviews Microbiol. 4, 477-486.

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Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse

Transcriptional Changes Common to Human Cocaine, Cannabis and Phencyclidine Abuse

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function of apoLs

Posted by epays on 08 Jan 2007 at 12:59 GMT