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They are CAK family members

Posted by Gerard_Manning on 19 Jun 2008 at 00:31 GMT

The kinase domains of ACAD10 and ACAD11 appear to be most similar to a choline kinase or an aminoglycoside phosphotransferase (APH) domain
http://plosone.org/article/info:doi/10.1371/journal.pone.0001597#article1.body1.sec2.p7

Both choline kinases (ChoK) and APHs have been classified into a much larger CAK family (Natarajan et al, PLoS Biol (2007) 5(3):e17). These ACADs, and their eukaryotic orthologs, do not have specific similarity to either the APHs or ChoKs, and so are unlikely to inherit their specific functional characteristics, other than a likely non-protein substrate (this is why they are omitted from our human kinome list). Many other non-APH, non-ChoK sub-families exist within CAK, including several found in selected eukaryotic lineages.