Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)

Ankit Gupta; Pruthvi Nagilla; Hai-Son Le; Coulton Bunney; Courtney Zych; Anbupalam Thalamuthu; Ziv Bar-Joseph; Sinnakaruppan Mathavan; Velpandi Ayyavoo

doi:10.1371/journal.pone.0022730

Loading metrics

Open Access

Peer-reviewed

Research Article

Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)

Ankit Gupta ,

Contributed equally to this work with: Ankit Gupta, Pruthvi Nagilla

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Pruthvi Nagilla ,

Contributed equally to this work with: Ankit Gupta, Pruthvi Nagilla

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Hai-Son Le,

Affiliation Department of Machine Learning, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
⨯
Coulton Bunney,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Courtney Zych,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Anbupalam Thalamuthu,

Affiliation Human Genetics, Genome Institute of Singapore, Singapore
⨯
Ziv Bar-Joseph,

Affiliation Department of Machine Learning, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
⨯
Sinnakaruppan Mathavan,

Affiliation Human Genetics, Genome Institute of Singapore, Singapore
⨯
Velpandi Ayyavoo

* E-mail: velpandi@pitt.edu

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)

Ankit Gupta,
Pruthvi Nagilla,
Hai-Son Le,
Coulton Bunney,
Courtney Zych,
Anbupalam Thalamuthu,
Ziv Bar-Joseph,
Sinnakaruppan Mathavan,
Velpandi Ayyavoo

Published: July 28, 2011
https://doi.org/10.1371/journal.pone.0022730

Reader Comments

Post a new comment on this article

Error

Posted by kwitwer1 on 05 Oct 2011 at 15:47 GMT

21 miRNAs and 444 mRNA more than 2-fold, with a statistical significance of p<0.05.
http://plosone.org/article/info:doi/10.1371/journal.pone.0022730#article1.front1.article-meta1.abstract1.p1

As per Table 3, only 16 miRNAs were differentially regulated with statistical significance of p<0.05. An additional five with p of 0.05 or greater are also listed in the Table.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Host cells
Is the Subject Area "Host cells" applicable to this article?

Thanks for your feedback.
Virus effects on host gene expression
Is the Subject Area "Virus effects on host gene expression" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Post-transcriptional gene regulation
Is the Subject Area "Post-transcriptional gene regulation" applicable to this article?

Thanks for your feedback.
MAPK signaling cascades
Is the Subject Area "MAPK signaling cascades" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.

Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)

Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Error

Posted by kwitwer1 on 05 Oct 2011 at 15:47 GMT