Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

Erhan Bilal; Raul Rabadan; Gabriela Alexe; Noriyuki Fuku; Hitomi Ueno; Yutaka Nishigaki; Yasunori Fujita; Masafumi Ito; Yasumichi Arai; Nobuyoshi Hirose; Andrei Ruckenstein; Gyan Bhanot; Masashi Tanaka

doi:10.1371/journal.pone.0002421

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Open Access

Peer-reviewed

Research Article

Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

Erhan Bilal,

Affiliation BioMaPS Institute, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Raul Rabadan,

Affiliation Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, United States of America
⨯
Gabriela Alexe,

Affiliation Computational Biology and Bioinformatics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
⨯
Noriyuki Fuku,

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan
⨯
Hitomi Ueno,

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan
⨯
Yutaka Nishigaki,

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan
⨯
Yasunori Fujita,

Affiliation Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
⨯
Masafumi Ito,

Affiliation Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
⨯
Yasumichi Arai,

Affiliation Department of Geriatric Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
⨯
Nobuyoshi Hirose,

Affiliation Department of Geriatric Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
⨯
Andrei Ruckenstein,

Affiliation Department of Physics, Boston University, Boston, Massachusetts, United States of America
⨯
Gyan Bhanot,

Affiliations BioMaPS Institute, Rutgers University, Piscataway, New Jersey, United States of America, Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey, United States of America, Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Masashi Tanaka

* E-mail: mtanaka@tmig.or.jp

Affiliation Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan
⨯

Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

Erhan Bilal,
Raul Rabadan,
Gabriela Alexe,
Noriyuki Fuku,
Hitomi Ueno,
Yutaka Nishigaki,
Yasunori Fujita,
Masafumi Ito,
Yasumichi Arai,
Nobuyoshi Hirose

Published: June 11, 2008
https://doi.org/10.1371/journal.pone.0002421

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Data Collection

Posted by M_Kano on 16 Feb 2011 at 14:59 GMT

Care must also be taken to make sure that data is not skewed towards different ages in different neighborhoods.

No competing interests declared.

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Haplogroups
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Mitochondrial DNA
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Single nucleotide polymorphisms
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Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

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Data Collection

Posted by M_Kano on 16 Feb 2011 at 14:59 GMT