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Research Article

The p53 Tumor Suppressor-Like Protein nvp63 Mediates Selective Germ Cell Death in the Sea Anemone Nematostella vectensis

  • Sandra Pankow,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Casimir Bamberger mail

    To whom correspondence should be addressed. E-mail: casimir.bamberger@bluewin.ch

    Affiliation: Sundgauallee 64, Freiburg, Germany

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  • Published: September 12, 2007
  • DOI: 10.1371/journal.pone.0000782

Reader Comments (2)

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Referee Comments: Referee 2 (Wolfgang Deppert)

Posted by PLoS_ONE_Group on 27 Sep 2007 at 22:50 GMT

Reviewer 2's Review (Wolfgang Deppert)

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The authors have performed an interesting study on the stress response of gametes in the sea anemone Nemostella vectensis, which led to the identification of three p53 related proteins, nvp53, nvp63 and nvp73. Comparative cross-species analysis revealed that nvp63 is the most archaic member of the p53 family, both in structure and function, which is responsible for UV-light induced apoptosis in gametes.
The data are clean, of high technical quality, and nicely presented. I do not have any criticism.

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N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.