Alpha-Synuclein Is a Cellular Ferrireductase

Paul Davies; Dima Moualla; David R. Brown

doi:10.1371/journal.pone.0015814

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Peer-reviewed

Research Article

Alpha-Synuclein Is a Cellular Ferrireductase

Paul Davies,

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯
Dima Moualla,

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯
David R. Brown

* E-mail: bssdrb@bath.ac.uk

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯

Alpha-Synuclein Is a Cellular Ferrireductase

Paul Davies,
Dima Moualla,
David R. Brown

Published: January 10, 2011
https://doi.org/10.1371/journal.pone.0015814

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Copper deficiency link to Parkinsonism

Posted by Julie_Royster on 21 Jan 2011 at 20:53 GMT

Bharucha et al (2008, J. Neurology 255:1957-1962, PMID: 19159062) found borderline-low-normal ceruloplasmin levels in patients who developed Parkinson’s disease at a younger age, whereas older PD patients showed higher ceruloplasmin levels equal to those of control subjects. This is consistent with the finding by Davies, Moualla & Brown that copper is necessary for the ferrireductase function.

No competing interests declared.

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Alpha-Synuclein Is a Cellular Ferrireductase

Alpha-Synuclein Is a Cellular Ferrireductase

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Copper deficiency link to Parkinsonism

Posted by Julie_Royster on 21 Jan 2011 at 20:53 GMT