Research Article

Oxytocin Increases Generosity in Humans

  • Paul J. Zak mail,

    To whom correspondence should be addressed. E-mail:

    Affiliations: Center for Neuroeconomics Studies and Department of Economics, Claremont Graduate University, Claremont, California, United States of America, Department of Neurology, Loma Linda University Medical Center, Loma Linda, California, United States of America

  • Angela A. Stanton,

    Affiliation: Argyros School of Business & Economics, Chapman University, Orange, California, United States of America

  • Sheila Ahmadi

    Affiliation: Division of Endocrinology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

  • Published: November 07, 2007
  • DOI: 10.1371/journal.pone.0001128

Reader Comments (6)

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Subgenual Oxytocin?

Posted by asfox on 21 Nov 2007 at 09:02 GMT

The subgenualis is dense in OT receptors

Am I correct in reading this to say that OT receptors are dense within BA 25? The work cited here does not seem to mention OT receptor density.

There is also a reference to OT in the anterior cingulate that calls upon references 48 & 49. I cannot find any reference to BA 25 in either of these papers. It may be that the authors are re-interpreting a figure from Loup et al. (1991).

Could the authors please be explicit about where they find evidence for this claim? I have seen this claim a couple of times, and have been having trouble finding empirical evidence. It is likely that I am just missing something.

- Andrew Fox

RE: Subgenual Oxytocin?

pzak replied to asfox on 22 Nov 2007 at 15:22 GMT

Hi, you are correct that the human subgenual cortex has a mass of OT receptors, but OT receptors are also found throughout the brain. The paper provides refs for this assertion, though the histological methods used are not that specific to OT receptor locations so there is some debate on locations. You are correct the primary reference is Loup et al 1991. My lab has preliminary fMRI evidence for a related social monetary transfer task and we get solid activation in BA25. The Moll PNAS fMRI paper on charitable giving also finds this, so several lines of evidence suggest--but do not prove--that BA25 is dense with OT receptors.