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The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

  • Stephanie J. Soscia,

    Affiliations: Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • James E. Kirby,

    Affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

    X
  • Kevin J. Washicosky,

    Affiliation: Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Stephanie M. Tucker,

    Affiliation: Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Martin Ingelsson,

    Affiliation: Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden

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  • Bradley Hyman,

    Affiliations: Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Mark A. Burton,

    Affiliations: Molecular Aging and Developmental Laboratory, Photonics Center, College of Engineering, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University, Boston, Massachusetts, United States of America

    X
  • Lee E. Goldstein,

    Affiliations: Molecular Aging and Developmental Laboratory, Photonics Center, College of Engineering, Boston University School of Medicine, Boston University, Boston, Massachusetts, United States of America, Boston University Alzheimer's Disease Center, Boston University, Boston, Massachusetts, United States of America

    X
  • Scott Duong,

    Affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Rudolph E. Tanzi mail,

    tanzi@helix.mgh.harvard.edu

    Affiliations: Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Robert D. Moir

    Affiliations: Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: March 03, 2010
  • DOI: 10.1371/journal.pone.0009505

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Comment from the PLoS ONE Editorial Staff

Posted by PLoS_ONE_Group on 07 Dec 2010 at 14:37 GMT

Following the publication of this article, it has been brought to our attention that the corresponding author Dr Tanzi and the Academic Editor, Dr Bush, have collaborated on different projects and publications over the last fifteen years, and that they are both members of the Research and Development Advisory Board of Prana Biotechnology.

In line with the PLoS ONE competing interests policy (http://www.plosone.org/st...), we consider this as a potential conflict of interest. We have therefore asked Section Editor Mark Cookson to carefully evaluate the peer review process of this article. Dr Cookson has confirmed that he is satisfied that the peer review process and the decision for publication are adequate.

We are therefore content that the review process was handled correctly by Dr Bush, and that his judgement was in no way affected by his relationship with Dr Tanzi.

No competing interests declared.