Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

Jeffrey A. Canter; Lana M. Olson; Kylee Spencer; Nathalie Schnetz-Boutaud; Brent Anderson; Michael A. Hauser; Silke Schmidt; Eric A. Postel; Anita Agarwal; Margaret A. Pericak-Vance; Paul Sternberg Jr.; Jonathan L. Haines

doi:10.1371/journal.pone.0002091

Loading metrics

Open Access

Peer-reviewed

Research Article

Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

Jeffrey A. Canter ,

* E-mail: jeff.canter@vanderbilt.edu

Affiliation Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Lana M. Olson,

Affiliation Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Kylee Spencer,

Affiliation Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Nathalie Schnetz-Boutaud,

Affiliation Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Brent Anderson,

Affiliation Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Michael A. Hauser,

Affiliation Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Silke Schmidt,

Affiliation Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Eric A. Postel,

Affiliation Duke Eye Center, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Anita Agarwal,

Affiliation Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Margaret A. Pericak-Vance,

Affiliation The Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Paul Sternberg Jr.,

Affiliation Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Jonathan L. Haines

Affiliation Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯

Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

Jeffrey A. Canter,
Lana M. Olson,
Kylee Spencer,
Nathalie Schnetz-Boutaud,
Brent Anderson,
Michael A. Hauser,
Silke Schmidt,
Eric A. Postel,
Anita Agarwal,
Margaret A. Pericak-Vance

Published: May 7, 2008
https://doi.org/10.1371/journal.pone.0002091

Reader Comments

Post a new comment on this article

Referee Comments: Referee 1

Posted by PLOS_ONE_Group on 12 May 2008 at 22:33 GMT

Referee 1's Review:

**********
N.B. These are the comments made by the referee when reviewing an earlier version of this paper. Prior to publication, the manuscript has been revised in light of these comments and to address other editorial requirements.
**********

I think that the authors have adequately addressed the concerns in the prior review and the paper is suitable for publication.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Macular degeneration
Is the Subject Area "Macular degeneration" applicable to this article?

Thanks for your feedback.
Alleles
Is the Subject Area "Alleles" applicable to this article?

Thanks for your feedback.
Mitochondrial DNA
Is the Subject Area "Mitochondrial DNA" applicable to this article?

Thanks for your feedback.
Medical risk factors
Is the Subject Area "Medical risk factors" applicable to this article?

Thanks for your feedback.
Genetic polymorphism
Is the Subject Area "Genetic polymorphism" applicable to this article?

Thanks for your feedback.
Mitochondrial genetics
Is the Subject Area "Mitochondrial genetics" applicable to this article?

Thanks for your feedback.

Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Referee Comments: Referee 1

Posted by PLOS_ONE_Group on 12 May 2008 at 22:33 GMT