Surprisingly High Specificity of the PPD Skin Test for M. tuberculosis Infection from Recent Exposure in The Gambia

Philip C. Hill; Roger H. Brookes; Annette Fox; Dolly Jackson-Sillah; Moses D. Lugos; David J. Jeffries; Simon A. Donkor; Richard A. Adegbola; Keith P. W. J. McAdam

doi:10.1371/journal.pone.0000068

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Open Access

Peer-reviewed

Research Article

Surprisingly High Specificity of the PPD Skin Test for M. tuberculosis Infection from Recent Exposure in The Gambia

Philip C. Hill ,

*To whom correspondence should be addressed. E-mail: phill@mrc.gm

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Roger H. Brookes,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Annette Fox,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Dolly Jackson-Sillah,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Moses D. Lugos,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
David J. Jeffries,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Simon A. Donkor,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Richard A. Adegbola,

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯
Keith P. W. J. McAdam

Affiliation Bacterial Diseases Programme, Medical Research Council Unit, Banjul, The Gambia
⨯

Surprisingly High Specificity of the PPD Skin Test for M. tuberculosis Infection from Recent Exposure in The Gambia

Philip C. Hill,
Roger H. Brookes,
Annette Fox,
Dolly Jackson-Sillah,
Moses D. Lugos,
David J. Jeffries,
Simon A. Donkor,
Richard A. Adegbola,
Keith P. W. J. McAdam

Published: December 20, 2006
https://doi.org/10.1371/journal.pone.0000068

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Robust methods for difficult questions

Posted by ratner on 27 Dec 2006 at 18:47 GMT

Responsiveness to M. tuberculosis exposure was analysed according to sleeping proximity to an index case using logistic regression
http://plosone.org/article/info:doi/10.1371/journal.pone.0000068#article1.front1.article-meta1.abstract1.sec2.p1

This study overcomes the difficulties of performing good TB epidemiology by using detailed case-finding (including assessing a gradient of exposure based on sleeping proximity) and robust statistical methods.

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Surprisingly High Specificity of the PPD Skin Test for M. tuberculosis Infection from Recent Exposure in The Gambia

Surprisingly High Specificity of the PPD Skin Test for M. tuberculosis Infection from Recent Exposure in The Gambia

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Robust methods for difficult questions

Posted by ratner on 27 Dec 2006 at 18:47 GMT