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Research Article

Cadherin-9 Is a Novel Cell Surface Marker for the Heterogeneous Pool of Renal Fibroblasts

  • Cornelia Thedieck,

    Affiliation: Section for Transplantation Immunology and Immunohematology, Center for Medical Research, University Medical Clinic, Tübingen, Germany

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  • Hubert Kalbacher,

    Affiliation: Medical and Natural Sciences Research Centre, University of Tübingen, Tübingen, Germany

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  • Markus Kuczyk,

    Affiliation: Department of Urology, University Medical Clinic, Tübingen, Germany

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  • Gerhard A. Müller,

    Affiliation: Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Göttingen, Germany

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  • Claudia A. Müller,

    Affiliation: Section for Transplantation Immunology and Immunohematology, Center for Medical Research, University Medical Clinic, Tübingen, Germany

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  • Gerd Klein mail

    To whom correspondence should be addressed. E-mail: gerd.klein@uni-tuebingen.de

    Affiliation: Section for Transplantation Immunology and Immunohematology, Center for Medical Research, University Medical Clinic, Tübingen, Germany

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  • Published: August 01, 2007
  • DOI: 10.1371/journal.pone.0000657

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Referee Comments: Referee 1

Posted by PLoS_ONE_Group on 09 Aug 2007 at 22:39 GMT


Reviewer 1's Review

The Authors evaluated the expression of cadherin-9 in various human cell lines and tissue. They conclude that Cadherin-9 represent a novel and reliable surface marker for fibroblast and its presence allow to distiunguish the heterogenic pool of renal fibroblast into resident and activated, immigrate bone marrow derived fibroblast precursor and cells in different stages of epithelial mesenchymal cells. This is an important issue that can surely will help the relative role of E-M transition during the course of nephropathies.

N.B. These are the general comments made by the reviewer when reviewing this paper. Specific points addressed during revision of the paper are not shown.