Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

Qinghe Chen; Suthakar Ganapathy; Karan P. Singh; Sharmila Shankar; Rakesh K. Srivastava

doi:10.1371/journal.pone.0015288

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Peer-reviewed

Research Article

Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

Qinghe Chen,

Affiliation Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
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Suthakar Ganapathy,

Affiliation Division of Radiation Biology, Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
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Karan P. Singh,

Affiliation Department of Biostatistics, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, United States of America
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Sharmila Shankar,

Affiliation Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
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Rakesh K. Srivastava

* E-mail: rsrivastava@kumc.edu

Affiliation Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯

Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

Qinghe Chen,
Suthakar Ganapathy,
Karan P. Singh,
Sharmila Shankar,
Rakesh K. Srivastava

Published: December 14, 2010
https://doi.org/10.1371/journal.pone.0015288

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This is interesting!

Posted by hexin on 27 Jan 2011 at 16:09 GMT

Our recent accepted data also confirmed the same conclusions that: 1. AKT suppression potentiates resveratrol's effect on breast cancer cells; And 2. In breast cancer cells with WT PTEN (MCF7 AND MDAMB-231), resveratrol showed better effects on induction of apoptosis, as well as on combination therapy with rapamycin/ly294002 than in breast cancer cells with pten null (BT549).
see: PMID: 21168265
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.

No competing interests declared.

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Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

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This is interesting!

Posted by hexin on 27 Jan 2011 at 16:09 GMT