Genetic Variation in Healthy Oldest-Old

Julius Halaschek-Wiener; Mahsa Amirabbasi-Beik; Nasim Monfared; Markus Pieczyk; Christian Sailer; Anita Kollar; Ruth Thomas; Georgios Agalaridis; So Yamada; Lisa Oliveira; Jennifer A. Collins; Graydon Meneilly; Marco A. Marra; Kenneth M. Madden; Nhu D. Le; Joseph M. Connors; Angela R. Brooks-Wilson

doi:10.1371/journal.pone.0006641

Loading metrics

Open Access

Peer-reviewed

Research Article

Genetic Variation in Healthy Oldest-Old

Julius Halaschek-Wiener,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Mahsa Amirabbasi-Beik,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Nasim Monfared,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Markus Pieczyk,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Christian Sailer,

Affiliations Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, Institute of Plant Biology, University of Zürich, Zürich, Switzerland
⨯
Anita Kollar,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Ruth Thomas,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Georgios Agalaridis,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
So Yamada,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Lisa Oliveira,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Jennifer A. Collins,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Graydon Meneilly,

Affiliation Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Marco A. Marra,

Affiliation Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Kenneth M. Madden,

Affiliation Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
⨯
Nhu D. Le,

Affiliation Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
Joseph M. Connors,

Affiliation Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
⨯
[ ... ],
Angela R. Brooks-Wilson

* E-mail: abrooks-wilson@bcgsc.ca

Affiliations Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada
⨯
[ view all ]
[ view less ]

Genetic Variation in Healthy Oldest-Old

Julius Halaschek-Wiener,
Mahsa Amirabbasi-Beik,
Nasim Monfared,
Markus Pieczyk,
Christian Sailer,
Anita Kollar,
Ruth Thomas,
Georgios Agalaridis,
So Yamada,
Lisa Oliveira

Published: August 14, 2009
https://doi.org/10.1371/journal.pone.0006641

Reader Comments

Post a new comment on this article

GENETIC VARIATION

Posted by Diego_Albani on 01 Sep 2009 at 14:56 GMT

I JUST WANT TO ASK THE AUTHORS TO COMMENT ABOUT THIS POINT: HOW CAN THEY EXCLUDE THAT THE VARIANTS THEY FOUND ARE NOT SIMPLY FREQUENT POLYMORPHISMS IN THE GENERAL POPULATION? THANKS

No competing interests declared.

RE: GENETIC VARIATION

ABrooks-Wilson replied to Diego_Albani on 01 Sep 2009 at 23:52 GMT

Hello Diego. You are right -- we cannot tell from this data whether a variant is a common polymorphism or not. An association study comparing these healthy oldest old to the general population would be required to determine this.

No competing interests declared.

RE: RE: GENETIC VARIATION

Diego_Albani replied to ABrooks-Wilson on 02 Sep 2009 at 13:22 GMT

Ok, we agree

Good luck for your research

Best

Diego

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Aging
Is the Subject Area "Aging" applicable to this article?

Thanks for your feedback.
Genetic polymorphism
Is the Subject Area "Genetic polymorphism" applicable to this article?

Thanks for your feedback.
Tumor suppressor genes
Is the Subject Area "Tumor suppressor genes" applicable to this article?

Thanks for your feedback.
Aging and cancer
Is the Subject Area "Aging and cancer" applicable to this article?

Thanks for your feedback.
DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Genetics of disease
Is the Subject Area "Genetics of disease" applicable to this article?

Thanks for your feedback.
Genetics
Is the Subject Area "Genetics" applicable to this article?

Thanks for your feedback.

Genetic Variation in Healthy Oldest-Old

Genetic Variation in Healthy Oldest-Old

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

GENETIC VARIATION

Posted by Diego_Albani on 01 Sep 2009 at 14:56 GMT

RE: GENETIC VARIATION

ABrooks-Wilson replied to Diego_Albani on 01 Sep 2009 at 23:52 GMT

RE: RE: GENETIC VARIATION

Diego_Albani replied to ABrooks-Wilson on 02 Sep 2009 at 13:22 GMT