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Referee Comments: Referee 3 (Karol Sestak)

Posted by PLOS_ONE_Group on 20 Dec 2007 at 18:39 GMT

Reviewer 3's Review

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Authors present a potentially interesting study that is providing some new insight in respect to one of the hallmarks of intestinal barrier damage (ZO-1) by studying the gnotobiotic mouse model of IBD. Authors are trying their best to arrive to conclusions (occasionally exploiting overstatements that need to be toned down) that administration of EcN probiotic has beneficial impact on colitis and that ZO-1 marker can be instrumental in measuring such effects. Unfortunately, manuscript suffers with some English and scientific language problems that need to be resolved before study can be considered for publication.

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N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.