Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child

Open Access

Peer-reviewed

Research Article

Régine P. Steegers-Theunissen ,

* E-mail: r.steegers@erasmusmc.nl

Affiliations Obstetrics and Gynecology/Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, Clinical Genetics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Sylvia A. Obermann-Borst,

Affiliation Obstetrics and Gynecology/Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
⨯
Dennis Kremer,

Affiliation Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Jan Lindemans,

Affiliation Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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Cissy Siebel,

Affiliation Child Health Care Center CAREYN, Rotterdam, Netherlands
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Eric A. Steegers,

Affiliation Obstetrics and Gynecology/Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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P. Eline Slagboom,

Affiliation Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
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Bastiaan T. Heijmans

Affiliation Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
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Reader Comments

Quantitative traits according to maternal periconceptional folic acid use.
http://plosone.org/article/info:doi/10.1371/journal.pone.0007845#pone-0007845-t001

In Table 1 the units of the SAM and SAH concentrations should be given in nanomoles per liter instead of micromoles per liter.

No competing interests declared.

DNA methylation
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Folic acid
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Methylation
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Birth weight
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Epigenetics
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Beckwith-Wiedemann syndrome
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Child health
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Birth defects
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