Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

Taras K. Oleksyk; Kai Zhao; Francisco M. De La Vega; Dennis A. Gilbert; Stephen J. O'Brien; Michael W. Smith

doi:10.1371/journal.pone.0001712

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Open Access

Peer-reviewed

Research Article

Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

Taras K. Oleksyk ,

*E-mail: oleksyk@ncifcrf.gov

Affiliations Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Kai Zhao,

Affiliation Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Francisco M. De La Vega,

Affiliation Applied Biosystems, Foster City, California, United States of America
⨯
Dennis A. Gilbert,

Affiliation Applied Biosystems, Foster City, California, United States of America
⨯
Stephen J. O'Brien,

Affiliation Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
Michael W. Smith

Affiliations Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯

Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

Taras K. Oleksyk,
Kai Zhao,
Francisco M. De La Vega,
Dennis A. Gilbert,
Stephen J. O'Brien,
Michael W. Smith

Published: March 5, 2008
https://doi.org/10.1371/journal.pone.0001712

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Sample size and inbreeding

Posted by Sher on 10 Apr 2008 at 15:54 GMT

It would be interesting to know what sample sizes would be necessary to detect selection events given different background/baseline heterozygosities. Also, in an inbred population, if I understand this correctly, I assume we would be more likely to detect recent events.

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Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

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Sample size and inbreeding

Posted by Sher on 10 Apr 2008 at 15:54 GMT