Trans-Synaptic Spread of Tau Pathology In Vivo

Li Liu; Valerie Drouet; Jessica W. Wu; Menno P. Witter; Scott A. Small; Catherine Clelland; Karen Duff

doi:10.1371/journal.pone.0031302

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Open Access

Peer-reviewed

Research Article

Trans-Synaptic Spread of Tau Pathology In Vivo

Li Liu,

Affiliation Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
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Valerie Drouet,

Affiliation Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
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Jessica W. Wu,

Affiliation Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
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Menno P. Witter,

Affiliation Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway
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Scott A. Small,

Affiliation Department of Neurology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
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Catherine Clelland,

Affiliation Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America
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Karen Duff

* E-mail: ked2115@columbia.edu

Affiliations Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America, Department of Psychiatry, New York State Psychiatric Institute, New York, New York, United States of America
⨯

Trans-Synaptic Spread of Tau Pathology In Vivo

Li Liu,
Valerie Drouet,
Jessica W. Wu,
Menno P. Witter,
Scott A. Small,
Catherine Clelland,
Karen Duff

Published: February 1, 2012
https://doi.org/10.1371/journal.pone.0031302

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Implications for Patients?

Posted by docartemis on 02 Feb 2012 at 17:10 GMT

Like many people I read about this study in the New York Times. As a physician I am concerned that the applicability of this study will be greatly exaggerated.

What percentage of dementia patients actually have tauopathy?

I suspect we don't even have an estimate since the diagnosis of Alzheimer's Disease is usually presumed and never documented via autopsy.

Ginger Campbell, MD
Host of the Brain Science Podcast

No competing interests declared.

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Trans-Synaptic Spread of Tau Pathology In Vivo

Trans-Synaptic Spread of Tau Pathology In Vivo

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Implications for Patients?

Posted by docartemis on 02 Feb 2012 at 17:10 GMT