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Research Article

Trans-Synaptic Spread of Tau Pathology In Vivo

  • Li Liu,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Valerie Drouet,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Jessica W. Wu,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Menno P. Witter,

    Affiliation: Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway

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  • Scott A. Small,

    Affiliation: Department of Neurology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Catherine Clelland,

    Affiliation: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America

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  • Karen Duff mail

    ked2115@columbia.edu

    Affiliations: Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, United States of America, Department of Psychiatry, New York State Psychiatric Institute, New York, New York, United States of America

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  • Published: February 01, 2012
  • DOI: 10.1371/journal.pone.0031302

Reader Comments (3)

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Implications for Patients?

Posted by docartemis on 02 Feb 2012 at 17:10 GMT

Like many people I read about this study in the New York Times. As a physician I am concerned that the applicability of this study will be greatly exaggerated.

What percentage of dementia patients actually have tauopathy?

I suspect we don't even have an estimate since the diagnosis of Alzheimer's Disease is usually presumed and never documented via autopsy.

Ginger Campbell, MD
Host of the Brain Science Podcast

No competing interests declared.