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Referee Comments: Referee 1 (Graham Pockley)

Posted by PLOS_ONE_Group on 22 Nov 2007 at 09:52 GMT

Reviewer 1's Review (Graham Pockley)

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This study has investigated circulating levels of molecular chaperones in normal individuals and individuals with periodontal disease. The authors have also studied the effect treatment for periodontal disease on the circulating levels of these proteins. This study extends the previous work of the authors and adds to the literature in this area. The findings reported in this manuscript are novel and the experimental approach and statistical analysis appear to be valid and appropriate.

It would appear that the treatment of periodontal disease is a good model for acute inflammatory responses in the clinical setting, and this approach might provide insight into a number of mechanisms that potentiate and control such acute inflammatory events.

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N.B. These are the general comments made by the reviewer when reviewing this paper in light of which the manuscript was revised. Specific points addressed during revision of the paper are not shown.

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