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Research Article

A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle

  • Reijo Laaksonen mail,

    To whom correspondence should be addressed. E-mail: reijo.laaksonen@helsinki.fi (RL); matej.oresic@vtt.fi (MO)

    Affiliation: Research Unit, University Hospital of Tampere, Tampere, Finland

    X
  • Mikko Katajamaa,

    Affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

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  • Hannu Päivä,

    Affiliation: Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland

    X
  • Marko Sysi-Aho,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

    X
  • Lilli Saarinen,

    Affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

    X
  • Päivi Junni,

    Affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

    X
  • Dieter Lütjohann,

    Affiliation: Department of Clinical Pharmacology, University of Bonn, Bonn, Germany

    X
  • Joél Smet,

    Affiliation: Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium

    X
  • Rudy Van Coster,

    Affiliation: Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium

    X
  • Tuulikki Seppänen-Laakso,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

    X
  • Terho Lehtimäki,

    Affiliations: Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere, Finland, Centre for Laboratory Medicine, University Hospital of Tampere, Tampere, Finland, Medical School, University of Tampere, Tampere, Finland

    X
  • Juhani Soini,

    Affiliation: Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland

    X
  • Matej Orešič mail

    To whom correspondence should be addressed. E-mail: reijo.laaksonen@helsinki.fi (RL); matej.oresic@vtt.fi (MO)

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

    X
  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000097

Reader Comments (1)

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Q-value reference

Posted by John_Storey on 22 Dec 2006 at 02:38 GMT

q-value
http://plosone.org/article/info:doi/10.1371/journal.pone.0000097#article1.front1.article-meta1.abstract1.sec3.p1

Q-values are not universally known and there is no reference given here, so I am including the software's web site for the readers' convenience: http://faculty.washington.edu/jstorey/qvalue/