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Research Article

Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome

  • Steven E. Schutzer equal contributor mail,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    schutzer@umdnj.edu

    Affiliation: Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America

    X
  • Thomas E. Angel equal contributor,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Tao Liu equal contributor,

    equal contributor Contributed equally to this work with: Steven E. Schutzer, Thomas E. Angel, Tao Liu

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Athena A. Schepmoes,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Therese R. Clauss,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Joshua N. Adkins,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • David G. Camp II,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Bart K. Holland,

    Affiliation: Division of Biostatistics and Epidemiology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America

    X
  • Jonas Bergquist,

    Affiliation: Department of Physical and Analytical Chemistry, Uppsala University, Uppsala, Sweden

    X
  • Patricia K. Coyle,

    Affiliation: Department of Neurology, State University of New York-Stony Brook, Stony Brook, New York, United States of America

    X
  • Richard D. Smith,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Brian A. Fallon,

    Affiliation: Department of Psychiatry, Columbia University Medical Center, New York, New York, United States of America

    X
  • Benjamin H. Natelson

    Affiliations: Department of Neurology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey, United States of America, Department of Pain Medicine and Palliative Care and Beth Israel Medical Center, Albert Einstein School of Medicine, Bronx, New York, United States of America

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  • Published: February 23, 2011
  • DOI: 10.1371/journal.pone.0017287

Reader Comments (4)

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Complement activation in acute Lyme neuroborreliosis and in Post-Treatment Lyme Disease.

Posted by Henningsson on 08 Apr 2011 at 08:32 GMT

We read with interest the article concerning distinct differences in cerebrospinal fluid proteomes between patients with Neurologic Post Treatment Lyme disease syndrome and patients with Chronic Fatigue Syndrome.
We are pleased that the authors have been able to verify our C1q results in Lyme neuroborreliosis patients published in 2007 (Henningsson AJ, Ernerudh
J, Sandholm K et al. Complement activation in Lyme neuroborreliosis - Increased levels of C1q and C3a in cerebrospinal fluid indicate complement activation in the CNS. J Neuroimmunol 2007;183:200-7). While our samples were mostly taken during the acute phase of the disease, samples in the paper by Schutzer et al. were taken long (at least four months) after the acute phase, suggesting that changes in complement levels either may denote earlier infection or perhaps indicate ongoing aberrant inflammation. Further studies on the role of the complement system in Lyme neuroborreliosis pathogenesis are indeed needed.

AJ Henningsson
J Ernerudh
D Nyman
K Nilsson Ekdahl

No competing interests declared.