Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Otto Erlwein; Steve Kaye; Myra O. McClure; Jonathan Weber; Gillian Wills; David Collier; Simon Wessely; Anthony Cleare

doi:10.1371/journal.pone.0008519

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Research Article

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Otto Erlwein,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Steve Kaye,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Myra O. McClure ,

* E-mail: m.mcclure@imperial.ac.uk

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
⨯
Jonathan Weber,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
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Gillian Wills,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London, United Kingdom
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David Collier,

Affiliation Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry (King's College London) De Crespigny Park, Denmark Hill, London, United Kingdom
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Simon Wessely,

Affiliation Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom
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Anthony Cleare

Affiliation Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom
⨯

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Otto Erlwein,
Steve Kaye,
Myra O. McClure,
Jonathan Weber,
Gillian Wills,
David Collier,
Simon Wessely,
Anthony Cleare

Published: January 6, 2010
https://doi.org/10.1371/journal.pone.0008519

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Different XMRV sequences targeted for amplification

Posted by MDMS on 08 Jan 2010 at 23:59 GMT

My understaning from reading this study, the prior CFS/ XMRV study, and recent commentary is that the XMRV region targeted for amplification in this study is different from that targeted in the initial study. While using a different region for amplification may give another look at the situation, since this was a replication study, why was not the same XMRV region examined?

No competing interests declared.

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Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

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Different XMRV sequences targeted for amplification

Posted by MDMS on 08 Jan 2010 at 23:59 GMT