Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection

Colleen A. Fisher; Eric K. Bhattarai; Jason B. Osterstock; Scot E. Dowd; Paul M. Seabury; Meenu Vikram; Robert H. Whitlock; Ynte H. Schukken; Robert D. Schnabel; Jeremy F. Taylor; James E. Womack; Christopher M. Seabury

doi:10.1371/journal.pone.0027744

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Open Access

Peer-reviewed

Research Article

Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection

Colleen A. Fisher,

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, United States of America
⨯
Eric K. Bhattarai,

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, United States of America
⨯
Jason B. Osterstock,

Affiliation Pfizer Animal Genetics, Kalamazoo, Michigan, United States of America
⨯
Scot E. Dowd,

Affiliation Research and Testing Laboratory, SpiroStat Technologies, Medical Biofilm Research Institute, Lubbock, Texas, United States of America
⨯
Paul M. Seabury,

Affiliation ElanTech, Inc., Greenbelt, Maryland, United States of America
⨯
Meenu Vikram,

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, United States of America
⨯
Robert H. Whitlock,

Affiliation Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, United States of America
⨯
Ynte H. Schukken,

Affiliation Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
⨯
Robert D. Schnabel,

Affiliation Division of Animal Sciences, University of Missouri, Columbia, Missouri, United States of America
⨯
Jeremy F. Taylor,

Affiliation Division of Animal Sciences, University of Missouri, Columbia, Missouri, United States of America
⨯
James E. Womack,

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, United States of America
⨯
Christopher M. Seabury

* E-mail: cseabury@cvm.tamu.edu

Affiliation Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, United States of America
⨯

Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection

Colleen A. Fisher,
Eric K. Bhattarai,
Jason B. Osterstock,
Scot E. Dowd,
Paul M. Seabury,
Meenu Vikram,
Robert H. Whitlock,
Ynte H. Schukken,
Robert D. Schnabel,
Jeremy F. Taylor

Published: November 30, 2011
https://doi.org/10.1371/journal.pone.0027744

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Publisher's Note: Error in Figure 1 legend.

Posted by PLOS_ONE_Group on 12 Jan 2012 at 17:20 GMT

For validated bovine TLR SNPs detected via pyrosequencing (n = 244), a regression analysis was performed for pyrosequencing allele frequency (AF) estimates corresponding to the true minor alleles.
http://plosone.org/article/info:doi/10.1371/journal.pone.0027744#pone-0027744-g001

The bold text in the legend of Figure 1 should not be formatted as a heading. The text is part of the body of the legend. The correct first sentence of the legend is: For validated bovine TLR SNPs detected via pyrosequencing (n = 244), a regression analysis was performed for pyrosequencing allele frequency (AF) estimates corresponding to the true minor alleles (<0.5), as defined by allele-specific genotyping assays, and minor AFs (MAFs) directly ascertained by genotyping (n = 96 elite sires; 31 breeds).

No competing interests declared.

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Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection

Evolution of the Bovine TLR Gene Family and Member Associations with Mycobacterium avium Subspecies paratuberculosis Infection

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Publisher's Note: Error in Figure 1 legend.

Posted by PLOS_ONE_Group on 12 Jan 2012 at 17:20 GMT