Sp1 Is Essential for p16INK4a Expression in Human Diploid Fibroblasts during Senescence

Junfeng Wu; Lixiang Xue; Mo Weng; Ying Sun; Zongyu Zhang; Wengong Wang; Tanjun Tong

doi:10.1371/journal.pone.0000164

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Peer-reviewed

Research Article

Sp1 Is Essential for p16^INK4a Expression in Human Diploid Fibroblasts during Senescence

Junfeng Wu ,

Contributed equally to this work with: Junfeng Wu, Lixiang Xue

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯
Lixiang Xue ,

Contributed equally to this work with: Junfeng Wu, Lixiang Xue

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯
Mo Weng,

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯
Ying Sun,

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯
Zongyu Zhang,

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯
Wengong Wang ,

*To whom correspondence should be addressed. E-mail: wwg@bjmu.edu.cn (WW); ttj@bjmu.edu.cn (TT)

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯
Tanjun Tong

*To whom correspondence should be addressed. E-mail: wwg@bjmu.edu.cn (WW); ttj@bjmu.edu.cn (TT)

Affiliation Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing, China
⨯

Sp1 Is Essential for p16^INK4a Expression in Human Diploid Fibroblasts during Senescence

Junfeng Wu,
Lixiang Xue,
Mo Weng,
Ying Sun,
Zongyu Zhang,
Wengong Wang,
Tanjun Tong

Published: January 17, 2007
https://doi.org/10.1371/journal.pone.0000164

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Posted by tztong on 23 Jul 2009 at 07:11 GMT

Ohta K, Maruyama T, Uchida H, Ono M, et al. Glycodelin blocks progression to S phase and inhibits cell growth: a possible progesterone-induced regulator for endometrial epithelial cell growth. Molecular Human Reproduction 2008, 14(1):17-22; doi:10.1093/molehr/gam081

JY Chuang, CH Wu, MD Lai, WC Chang, JJ Hung.- Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells International Journal of Cancer, 2009

M. Witcher, B. Emerson. Epigenetic Silencing of the p16INK4a Tumor Suppressor Is Associated with Loss of CTCF Binding and a Chromatin Boundary. Molecular Cell,2009, 34 (3): 271-284

No competing interests declared.

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Gene expression
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Sp1 Is Essential for p16^INK4a Expression in Human Diploid Fibroblasts during Senescence

Sp1 Is Essential for p16^INK4a Expression in Human Diploid Fibroblasts during Senescence

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Posted by tztong on 23 Jul 2009 at 07:11 GMT